Isotretinoin, depression and suicide: a review of the evidence

Title: Isotretinoin, depression and suicide: a review of the evidence
Creator: Magin, Parker; Pond, Dimity; Smith, Wayne
Relation: British Journal of General Practice Vol. 55, no. 511, p. 134-138
Publisher: Royal College of General Practitioners
Resource Type: journal article
Date: 2005
Description: There is currently considerable controversy regarding a proposed causal relationship between the use of isotretinoin and depression and suicide. A search was made of the MEDLINE, EMBASE and PsychINFO databases using the search terms 'isotretinoin', 'depression' and 'suicide'. Despite numerous case reports linking isotretinoin to depression, suicidal ideation and suicide, there is, as yet, no clear proof of an association. While isotretinoin, used to treat acne vulgaris, has not been demonstrated to be associated with depression or suicide, the possibility of a relatively rare idiosyncratic adverse effect,remains. GPs have a role in the clinical application of these findings.
Subject: acne vulgaris; depression; isotretinoin; suicide; national-comorbidity-survey; acne-vulgaris; psychotic symptoms; risk-factors; therapy; adolescents; prevalence; disorder; accutane; anxiety
Identifier: uon:372
Identifier: http://hdl.handle.net/1959.13/25373
Identifier: ISSN:0960-1643
Language: eng
Reviewed

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